Explore panels that may explain frequent, severe, or unusual infections and provide insights for your doctor.
Immunodeficiency disorders occur when the immune system cannot effectively protect the body, often leading to frequent or unusual infections.
The immune system is designed to defend the body against infection. When it doesn’t function properly, people may experience repeated or severe illnesses that don’t respond to typical care. These patterns can signal an underlying immunodeficiency.
Immunodeficiency testing panels look for genetic or biological markers that may contribute to weakened immune function. While results do not provide a diagnosis on their own, they can give doctors useful insights for further evaluation or referral. Common conditions connected to immune system function include:
Multiple sclerosis (MS) is a chronic neurological and autoimmune disorder in which the immune system mistakenly attacks the protective covering (myelin) around nerve fibers in the brain, spinal cord, and optic nerves. Panels may measure immune activity markers such as cytokine levels or oligoclonal bands, which can reflect inflammation in the central nervous system.
Rheumatoid arthritis (RA) is an autoimmune disorder where the immune system attacks the joints, causing inflammation, pain, and swelling. Panels may include markers such as rheumatoid factor (RF) or anti-CCP antibodies that are often associated with RA.
Psoriatic arthritis is a form of arthritis linked to psoriasis, where the immune system contributes to joint pain and skin inflammation. Panels may look for the HLA-B27 gene and other immune-related markers that can be associated with the condition.
Ulcerative colitis is a chronic inflammatory bowel disease (IBD) that causes inflammation and sores in the colon lining. Panels may measure antibodies such as p-ANCA or other immune markers tied to IBD.
Celiac disease is an autoimmune condition where eating gluten triggers an immune response that damages the small intestine. Genetic testing often includes HLA-DQ2 and HLA-DQ8 variants, which are strongly associated with celiac disease.
Chronic bronchitis is long-term inflammation of the airways, often marked by a persistent cough and mucus production. Panels may evaluate immunoglobulin levels (IgG, IgA, IgM) to see if immune deficiencies contribute to recurring lung infections.
Crohn’s disease is another type of IBD that can affect any part of the digestive tract. Panels sometimes measure ASCA antibodies and other markers that may appear in Crohn’s.
Lupus is a systemic autoimmune disease that can affect the skin, joints, kidneys, brain, and other organs. Panels may look for ANA (antinuclear antibodies), which are commonly associated with lupus activity.
Pernicious anemia is an autoimmune disorder that prevents the body from absorbing enough vitamin B12. Testing may include intrinsic factor antibodies and parietal cell antibodies, which can interfere with absorption.
Immunodeficiency testing is one part of your care journey. We’ll connect you with trusted labs and resources so you and your doctor can make the next decision with clarity.
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